Correlation of peripheral neurotoxicity of utidelone-induced in the treatment of potients with advanced HER-2 negative breast cancer
10.13699/j.cnki.1001-6821.2024.24.005
- VernacularTitle:优替德隆治疗晚期HER-2阴性乳腺癌患者所致周围神经毒性的相关性研究
- Author:
Na-ni LI
1
;
Wei-nan XIE
;
Chao-guang HE
;
Jing HUANG
;
Gui-hua CAO
;
Yi-cong LIN
Author Information
1. 福建医科大学肿瘤临床医学院/福建省肿瘤医院乳腺内科,福建 福州 350011
- Publication Type:Journal Article
- Keywords:
utidelone injection;
peripheral neuropathy;
breast cancer;
related risk factor
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(24):3543-3547
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the peripheral neurotoxicity of utidelone(UTD-1)in patients with human epidermal growth factor receptor 2(HER-2)negative advanced breast cancer and its related factors.Methods The patients with HER-2 negative advanced breast cancer treated by UTD-1 were collected.The patients were divided into control group(low neurotoxicity group,grade 0-1 peripheral neurotoxicity)and treatment group(high neurotoxicity group,grade 2-4 peripheral neurotoxicity)according to cohort method.The data involve age,body mass index(BMI),related indicators of metabolic syndrome(MS)before chemotherapy,hormone receptor expression status of tumor,number of treatment lines,and whether combined with capecitabine were collected.The highest level of neurotoxicity after UTD-1 was collected for each patient,and the possible related factors were analyzed.Results There were 83 cases in the treatment group and 84 cases in the control group.The BMI of treatment and control groups were(24.81±1.93)and(22.82±2.19)kg·m-2,the fasting plasma glucose(FPG)levels were(6.45±1.37)and(5.42±0.79)mmol·L-1,the C-reaction protein(CRP)levels were 11.10 and 1.60 mg·L-1,respectively,and the differences were statistically significant(allP＜0.01).Multi-factor Logistics stepwise regression analysis showed that the high neurotoxicity group was independently correlated with high BMI,high FPG and high CRP(odds ratios were 11.51,7.78 and 6.88).Conclusion BMI,CRP and FPG may be independent risk factors for high peripheral neurotoxicity iduced by UTD-1.
