Advances in Research on Interleukin-22 in Inflammatory Bowel Disease
10.3969/j.issn.1008-7125.2024.10.010
- VernacularTitle:白细胞介素-22在炎症性肠病中的研究进展
- Author:
Kejing CAO
1
;
Yingwei CHEN
Author Information
1. 上海交通大学医学院附属新华医院消化内科(200092)
- Publication Type:Journal Article
- Keywords:
Interleukin-22;
Inflammatory Bowel Disease;
Colorectal Neoplasms
- From:
Chinese Journal of Gastroenterology
2024;29(10):631-636
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD)is a chronic and recurrent intestinal inflammatory disease.Interleukin(IL)-22,a member of the IL-10 family,protects the intestinal epithelial barrier and maintains intestinal homeostasis.Multiple studies have demonstrated that IL-22 induces inflammation and promotes inflammatory-cancerous transformation of IBD in different settings.IL-22 is involved in colorectal cancer(CRC)development,and it is a potential anti-cancer therapeutic target.This article reviewed the research progress of IL-22 in IBD.
