The correlation of cognitive function, P300 and cerebrum gray matter volume in schizophrenic patients
10.3760/cma.j.issn.1006-7884.2014.06.009
- VernacularTitle:精神分裂症患者认知功能、听觉事件诱发电位P300和脑灰质体积的相关分析
- Author:
Bingkui ZHANG
1
;
Fang LIU
;
Yuqi CHENG
;
Na LI
;
Hongjun YU
;
Chunrong LUO
;
Xiufeng XU
Author Information
1. 昆明市精神病院
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Cognition disorders;
Event-related potentials,P300;
Neuropsychological tests;
Cerebrum gray matter volume
- From:
Chinese Journal of Psychiatry
2014;47(6):352-358
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate cognitive impairment and the association with the grey matter volume in schizophrenia patients (NAS) with residual symptoms after antipsychotic drug treatment.Methods Eighteen NAS patients and 18 controls matched with age and education were recruited.Each subject was measured by neuropsychological cognitive tests,auditory event-evoked potential (P300) and MRI scans.The patient's symptoms were evaluated by using the PANSS and Clinical Global Impression Scale-Severity (CGI-S),while the side-effects of antipsychotics were evaluated by using the Extrapyramidal Side Effects Scale (SAS).Abnormal Involuntary Movement Scale (AIMS) and Barnes Akathisia Rating Scale (BARS).Then the difference between patients and controls and the associations between different measures were analyzed.Results Compared with control group,NAS patients showed abnormalities in most of the neuropsychological tests,including the poor performance in Continuous Performance Test (CPT):2-D,3-D (2.5 ±1.2,2.1±1.2 vs.3.5 ±0.6,2.9 ±0.8 for2-D,t=-3.088,-2.563,both P＜0.05) and the Stroop color word interference test (77.1 ± 16.6,32.4 ± 7.3,32.4 ± 7.3 vs.89.3 ± 8.9,41.8 ± 6.8,41.8 ± 6.8,t =-2.733,-4.015,-4.015,all P ＜ 0.05).The patients also showed poorer performance in groove nail plate test (69.8 ± 10.9,77.3 ± 11.4 vs.56.7 ± 7.1,68.7 ± 10.9,t =-4.015,2.313,both P ＜0.05),Color connection test (46.3 ± 18.1 vs.37.4 ± 10.6,t =4.638,P ＜ 0.05) and Category fluency test (11.8 ± 5.1 vs.15.6 ± 3.5,t =-2.593,P ＜ 0.05).NAS patients showed longer P300 N2 latency (237.1 ± 19.6) than controls (217.6 ± 26.5,t =2.966,P ＜ 0.05) while no difference on amplitude between groups.Further analyses showed the positive correlation between P30o amplitude and the performance of the maze test,the color of the connection test and the correct number of Wisconsin card number test (r =0.493,0.527,0.512,all P ＜ 0.05),while negative correlations were also found with the wrong number of Wisconsin card number test and groove nail plate test (r =-0.571,-0.512,both P ＜ 0.05).Finally we found that the P300 latency was related to regional gray matter volume at the right superior temporal gyrus and middle temporal gyrus,right posterior lobe of the cerebellar tonsils,and the second half of lobular.Conclusion There may be extensively damage in cognitive function of the patients.
