Relationship between TPX2 with tumor microenvironment

VernacularTitle:TPX2与肿瘤微环境的关系
Author: Yu WU ¹ ; Hairong DONG ; Xiulan SU
Author Information

1. 内蒙古医科大学附属医院临床医学研究中心/自治区生物活性肽工程实验室,呼和浩特 010050
Publication Type:Journal Article
Keywords: TPX2; Tumor microenvironment; PI3K; Wnt
From: Chinese Journal of Immunology 2025;41(6):1531-1536,后插1
CountryChina
Language:Chinese
Abstract: Tumor microenvironment(TME)is the living environment of tumor cells.The immune cells contained in TME are reprogrammed into tumor-promoting states due to various factors.Inhibiting this reprogramming effect of TME is an innovative strategy for treating tumors.As an essential factor in spindle assembly,TPX2 is considered to be a gene that promotes cancer cell proliferation and plays a role in cell response to replication stress.Highly expressed TPX2 in tumor cells promotes tumor growth through a variety of pathways,and these pathways can promote the tumor-promoting activity of immune cells in TME.Therefore,TPX2 may be a regulatory gene of TME.This paper discusses the possible mechanism of TPX2 involved in the regulation of TME by discussing the pathway medi-ated by TPX2 and the regulation of immune cells infiltrated in TME,and provides ideas for subsequent research directions.