Corylifol A ameliorates Lewis lung carcinoma induced cachexia in mice
- VernacularTitle:次苷酸查尔酮对Lewis肺癌恶病质的改善作用
- Author:
Nan LI
1
;
Rui-qin ZHANG
;
Ke YU
;
Qiong-sen WANG
;
Xiao CHEN
;
Xiong-wen ZHANG
;
Xuan LIU
Author Information
- Publication Type:Journal Article
- Keywords: cancer cachexia; Lewis lung carcinoma; corylifol A; C2C12 cells; muscle atrophy; TAOK1
- From: Chinese Pharmacological Bulletin 2025;41(9):1672-1679
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the therapeutic effects of corylifol A(CYA)on Lewis lung carcinoma(LLC)cachexia mice and its ameliorating effects on myotube atrophy induced by LLC cell-conditioned medium(LLC CM)in vitro,and to explore the mechanisms.Methods The cancer cachexia was induced by subcu-taneous inoculation of LLC cells to C57BL/6J mice.The effects of CYA(10,20 mg·kg-1·d-1,i.p.)on the cachexia symptoms and survival time of cachexia mice were observed.The effects of 2.5 or 5 μmol·L-1 CYA on myotube atrophy of C2C12 induced by LLC CM were observed.The effects of CYA on its pos-sible target the serine/threonine-protein kinase TAO1(TAOK1)and downstream signaling pathways were detected using Western blot.The influence of TAOK1 knockout on the ameliorating effects of CYA on myo-tube atrophy was observed.Results CYA could sig-nificantly prolong the survival time of tumor-bearing mice and ameliorate the muscle atrophy associated with LLC.The effects of CYA on myotube atrophy are relat-ed to its regulation of TAOK1.The effects of CYA could be reduced by knockout of TAOK1.Conclusions CYA improves the survival of LLC cachexia mice and ameliorates the related skeletal muscle atrophy.The mechanism of CYA is related to its inhibition on TAOK1 and downstream signaling pathways.
