Dynamic contrast enhanced MRI for preoperative predicting microvascular invasion in hepatocellular carcinoma
10.13929/j.issn.1672-8475.2024.12.009
- VernacularTitle:动态增强MRI术前预测肝细胞癌微血管浸润
- Author:
Zhecheng CHENG
1
;
Min HU
;
Shengquan LING
;
Di WANG
;
Wei WEI
Author Information
1. 黄山市人民医院CT/MRI室,安徽黄山 245000
- Publication Type:Journal Article
- Keywords:
carcinoma,hepatocellular;
magnetic resonance imaging;
microvascular invasion
- From:
Chinese Journal of Interventional Imaging and Therapy
2024;21(12):767-771
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of dynamic contrast enhanced MRI(DCE-MRI)for preoperative predicting microvascular invasion(MVI)in hepatocellular carcinoma(HCC).Methods Sixty-eight HCC lesions in 66 patients(64 with single and 2 with 2 lesions)confirmed by surgery and pathology were retrospectively enrolled and were divided into MVI-positive group(n=17)and MVI-negative group(n=51)according to pathological results.Preoperative DCE-MRI qualitative and quantitative parameters of lesions were compared between groups,and the independent risk factors related to preoperative DCE-MRI features of HCC MVI were screened by multivariate binary logistic regression analysis,then a combined model was established.Receiver operating characteristic(ROC)curve was plotted,and the area under the curve(AUC)was calculated to evaluate the predictive efficacy of single independent risk factor and combined model.Results DCE-MRI showed that the proportion of irregular shape,incomplete pseudocapsule,intratumoral necrosis,peritumoral satellite nodules,transient hepatic parenchymal enhancement in arterial phase and mosaic appearance in MVI-positive group were all higher than those in MVI-negative group,the maximum diameter of lesions in MVI-positive group was larger than that in MVI-negative group,while portal-phase enhancement washout(PEW),absolute enhancement washout(AEW)and relative enhancement washout(REW)in MVI-positive group were all lower than those in MVI-negative group(all P＜0.05).Peritumoral satellite nodules(OR=33.777,P=0.003),the maximum diameter of lesion≥4.25 cm(OR=6.429,P=0.038)and REW≤0.15(OR=6.148,P=0.028)were all independent risk factors of MVI in HCC.The AUC of the above single independent risk factors and combined model was 0.755,0.719,0.781 and 0.897,respectively.Conclusion DCE-MRI could effectively preoperatively predict MVI in HCC.
