Research Advances on the Mechanism of Thrombus Associated With Patent Foramen Ovale
10.3969/j.issn.1000-3614.2025.08.015
- VernacularTitle:卵圆孔未闭相关性血栓形成机制的研究现状
- Author:
Zhengwei LI
1
;
Haibo HU
1
;
Xiangbin PAN
1
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 结构性心脏病中心,北京 100037
- Publication Type:Journal Article
- Keywords:
patent foramen ovale;
thrombus;
mechanism;
stroke
- From:
Chinese Circulation Journal
2025;40(8):823-827
- CountryChina
- Language:Chinese
-
Abstract:
Patent foramen ovale(PFO)is a common congenital heart disease.As research on PFO continues to deepen,it has been found that PFO is associated with various diseases such as stroke,migraines,and decompression sickness.It is known that when a thrombus in the vein directly enters the arterial circulation through the PFO,paradoxical embolism occurs in the systemic circulation,with stroke being the most common disease form.Studies have found that PFO patients have a relatively higher risk of thrombosis formation,although the mechanism is not fully understood.Previous and current PFO-related research indicates that when blood flows through the PFO,the flow is slow and turbulent,causing damage to the endothelium of the PFO channel;when venous blood bypasses the filtering function of the lungs and enters the systemic circulation through the PFO,this blood contains a large amount of impurities,leading to a hypercoagulable state of the blood;in addition,PFO patients have an increased susceptibility to atrial fibrillation,increasing their risk of thrombosis formation.This article aims to explore the mechanism of PFO-related thrombus formation.Understanding the mechanism might help reduce the risk of thrombosis formation and subsequently reduce the incidence of PFO-related diseases in clinical practice.
