Clinical Comprehensive Evaluation of Three Inhalation Triple Preparations for the Treatment of Chronic Obstructive Pulmonary Disease
10.3870/j.issn.1004-0781.2025.09.019
- VernacularTitle:3种吸入用三联制剂治疗慢性阻塞性肺疾病的临床综合评价
- Author:
Lina ZHANG
1
;
Yujie SUO
;
Xiaohong LI
;
Zhiqiang YE
;
Hua YAN
Author Information
1. 华北医疗健康集团峰峰总医院药学部,邯郸 056000
- Publication Type:Journal Article
- Keywords:
Inhalation preparation;
Drug evaluation;
Chronic obstructive pulmonary disease;
Digital rating
- From:
Herald of Medicine
2025;44(9):1496-1503
- CountryChina
- Language:Chinese
-
Abstract:
Objective A comprehensive evaluation of three kinds of closed triple therapy(fluticasone furoate,umeclidinium bromide and vilanterol trifenatate powder for inhalation,budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol,beclometasone dipropionate,formoterol fumarate and glycopyrrolate inhalation aerosol)for stable maintenance treatment of chronic obstructive pulmonary disease(COPD)is conducted to provide reference for drug selection and rational clinical use in medical institutions.Methods Based on the Quick Guidelines for Drug Evaluation and Selection in Chinese Medical Institutions(Second Edition),this study collected drug instructions,clinical guidelines,and relevant literature from databases such as China National Knowledge Infrastructure(CNKI),Wanfang Database,VIP Database for Chinese Technical Periodicals(VIP),PubMed,Embase and Cochrane Library.Quantitative indicators were established to evaluate three inhalations that closed triple therapy formulations from five dimensions:effectiveness,pharmacological characteristics,safety,economy,and other attributes.Results The comprehensive scores of the formulations included in the evaluation are all above 80 points,among which the comprehensive score of fluticasone furoate,umeclidinium bromide and vilanterol trifenatate powder for inhalation is the highest at 89.2 points,followed by budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol at 87.6 points,and the lowest score of beclometasone dipropionate,formoterol fumarate and glycopyrrolate inhalation aerosol at 82.9 points.Conclusions All three formulations have shown good clinical efficacy,and different triple formulations have different advantages in clinical treatment.Through the comprehensive evaluation of three types of inhalation triple preparations,it can provide a reference for drug selection in medical institutions,and provide a basis for clinical scientific,rational,safe,and personalized medication.
