Research Progress on NAD+Regulation of Cellular Senescence Mechanisms and Idiopathic Pulmonary Fibrosis Disease
10.3870/j.issn.1672-0741.24.06.012
- VernacularTitle:NAD+调节细胞衰老机制与特发性肺纤维化疾病的研究进展
- Author:
Yushan LIU
1
;
Yilin ZHANG
1
;
Shusen YANG
1
Author Information
1. 陕西中医药大学基础医学院,咸阳 712046
- Publication Type:Journal Article
- Keywords:
NAD+;
cell senescence;
idiopathic pulmonary fibrosis;
oxidative stress;
DNA damage
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2024;53(6):852-857
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis(IPF)is a common interstitial fibrosis disease with poor prognosis and lack of effec-tive treatment to prolong the survival time of patients.Cell senescence can induce tissue inflammation and accelerate the patho-logical process of fibrosis.Excessive oxidative stress,nuclear DNA damage and mitochondrial dysfunction in the pathological en-vironment of IPF are the main causes of cell senescence.Nicotinamide adenine dinucleotide(NAD+)is an important coenzyme in redox reaction,which can regulate a series of biological functions by blocking cell senescence.Its active expression is closely re-lated to the occurrence and development of IPF.Therefore,to explore the mechanism of NAD+regulating cell senescence under pathological condition is of great significance for the prevention and treatment of IPF.
