Effect of repetitive transcranial magnetic stimulation on sleep structure and quality in children with autism spectrum disorder
10.3969/j.issn.1000-6729.2025.09.04
- VernacularTitle:重复经颅磁刺激对孤独症谱系障碍儿童睡眠结构及质量的影响
- Author:
Yan ZHANG
1
;
Juan YAN
;
Junjie WANG
;
Guidong ZHU
;
Jiang CAO
;
Kaijie FANG
;
Haidong SONG
Author Information
1. 丽水市第二人民医院,浙江丽水 323060
- Publication Type:Journal Article
- Keywords:
autism spectrum disorder;
repetitive transcranial magnetic stimulation;
sleep quality;
dorsolater-al prefrontal lobe
- From:
Chinese Mental Health Journal
2025;39(9):773-779
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of repetitive transcranial magnetic stimulation(rTMS)on sleep structure and quality in children with autism spectrum disorder(ASD).Methods:Sixty children with ASD who met the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5)criteria were randomly assigned to rTMS treatment group and pseudo-treatment group.The rTMS group received bilateral low-frequency(0.5 Hz)stimulation,and the pseudo-treatment group received pseudo-stimulation at the same time and place.Sleep quality and autism symptoms were assessed at baseline,midpoint(15 sessions),and endpoint(30 sessions),using the Childhood Sleep Disorders Scale(SDSC)and the Behavior Rating Scale for Children with Autism Spectrum Disorders(ABC)before treatment,15 times and 30 times of intervention,and statistical analysis was performed.Results:There was no significant difference in SDSC factor and total score between the two groups before treatment(P＞0.05).After 15 and 30 treatments,the total scores of SDSC and all factors were lower in the rTMS group than in the pseudo-treatment group(P＜0.05).Repeated measurement ANOVA found that there was an interaction be-tween the groups and the number of interventions,that is,the scores of the two groups had different downward trends,and the decline of the treatment group was more obvious than that of the pseudo-treatment group.There was no significant difference in the interaction between ABC scale scores and intervention times(P＞0.05).Conclu-sion:Repetitive transcranial magnetic stimulation significantly improves the sleep structure and quality in children with autism spectrum disorder.
