Study on the Correlation between of Ferritin-to-Albumin Ratio and In-Hospital Mortality among Critically Ill Patients
10.13241/j.cnki.pmb.2025.14.003
- VernacularTitle:重症患者铁蛋白/白蛋白比值与院内死亡率的相关性研究
- Author:
Yuan JIANG
1
;
Wei-ping XIA
;
Shu-ying QIU
Author Information
1. 中南大学湘雅医院重症医学科 湖南长沙 410008
- Publication Type:Journal Article
- Keywords:
Critically ill patients;
Intensive care unit;
In-hospital mortality;
Ferritin-to-albumin ratio;
Correlation
- From:
Progress in Modern Biomedicine
2025;25(14):2259-2268
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The serum ferritin-to-albumin ratio(FAR)has been proposed as a novel prognostic marker for sepsis,but its predictive role in outcomes among critically ill patients remains unclear.This study aimed to investigate the correlation between FAR and in-hospital mortality among critically ill patients.Methods:Based on the Medical Information Mart for Intensive Care-Ⅳ(MIMIC-Ⅳ),8,136 Intensive Care Unit(ICU)patients were included.Multivariate logistic regression was used to evaluate the predictive value of FAR for in-hospital mortality,and receiver operating characteristic(ROC)curve analysis was performed to compare its predictive performance with other parameters.Results:The overall in-hospital mortality was 2.31％.Multivariate logistic regression analysis showed that FAR was an independent predictor of in-hospital death(OR=2.190,95％CI=1.730-2.780,P=0.000).ROC analysis revealed that FAR achieved a significantly higher area under the curve(AUC)value(0.72)compared to ferritin(0.69)and albumin(0.26),with an optimal cutoff value of 80.57.Subgroup analysis demonstrated no significant interaction effects between FAR and most subgroups(P＞0.05),except for the hypertension subgroup.Conclusion:FAR is significantly associated with in-hospital mortality in critically ill patients,and elevated FAR values indicate an increased risk of death.
