Effects of Feilike Mixture Combined with Montelukast Sodium on Pulmonary Function and Inflammatory Immune Response in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
10.13241/j.cnki.pmb.2025.13.010
- VernacularTitle:肺力咳合剂联合孟鲁司特钠对慢性阻塞性肺疾病急性加重期患者肺功能和炎症免疫反应的影响
- Author:
Jie WANG
1
;
Shi-jian HUANG
1
;
Cong WANG
1
Author Information
1. 赣州市大余县人民医院呼吸内科 江西赣州 341500
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Acute exacerbation stage;
Feilike mixture;
Montelukast sodium;
Pulmonary function;
Immune function;
Inflammatory factor
- From:
Progress in Modern Biomedicine
2025;25(13):2167-2173
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of Feilike mixture combined with Montelukast sodium on pulmonary function and inflammatory immune response in patients with Acute exacerbation of Chronic obstructive Pulmonary Disease(AECOPD).Methods:82 patients with AECOPD were divided into control group and observation group,with 41 cases in each group by random number table method.The control group was treated with conventional treatment+Montelukast sodium,and the observation group was treated with Feilike mixture+conventional treatment+montelukast sodium.After two weeks,the clinical efficacy,pulmonary function,immune function,inflammatory factors,and treatment safety of the two groups were evaluated.Results:The total effective rate in observation group was higher than that in control group(P＜0.05).Ratio of Forced expiratory volume in the first second(FEV1)to forced vital capacity(FVC)(FEV1/FVC),FEV1,FEV1 percentage of estimated value(FEV1％pred)in observa tion group after treatment were higher than those in control group(P＜0.05).CD3+,CD4+,CD4+/CD8+in observation group after treatment were higher than those in control group,and CD8+was lower than that in control group(P＜0.05).The levels of pulmonary surfactant protein-A(SP-A),interleukin-17(IL-17)and Granulocyte colony-stimulating factor(G-CSF)in observation group after treatment were lower than those in control group(P＜0.05).There was no difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Feilike Mixture combined with Montelukast sodium can effectively improve pulmonary function and regulate inflammatory immune response in patients with AECOPD,with no obvious adverse reactions during the treatment.
