Application of prostate health index and prostate health index density in the detection of intermediate-to high-risk prostate cancer
10.3969/j.issn.1009-8291.2025.08.002
- VernacularTitle:前列腺健康指数和前列腺健康指数密度在中高危前列腺癌诊断中的应用
- Author:
Chenchen CHEN
1
;
Yinghao ZHOU
1
;
Yaozong XU
1
;
Yibo MENG
1
;
Guowei SHI
1
;
Jun ZHANG
1
;
Wandong YU
1
Author Information
1. 复旦大学附属上海市第五人民医院泌尿外科,上海 200240
- Publication Type:Journal Article
- Keywords:
prostate cancer;
intermediate-to high-risk prostate cancer;
prostate health index;
prostate health index density
- From:
Journal of Modern Urology
2025;30(8):642-647,700
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of prostate health index(PHI)and prostate health index density(PHID)in identifying intermediate-to high-risk prostate cancer(PCa).Methods Clinical data of 160 treatment-na?ve patients with highly suspected PCa,who underwent initial prostate biopsy in our hospital during Jul.2022 and Feb.2024,were retrospectively analyzed.Data included age,body mass index(BMI),prostate volume(PV),total prostate-specific antigen(tPSA),free PSA(fPSA),[-2]proPSA(p2PSA),PHI and PHID.Biopsy-positive results were stratified according to the EAU D'Amico risk criteria.Receiver operating characteristic(ROC)curve and multivariate logistic regression analysis were employed to assess the diagnostic performance of PHI and PHID in predicting PCa and identifying intermediate-to high-risk PCa.Results There were statistically significant differences in tPSA,p2PSA,PHI and PHID between the negative and positive groups,as well as among the low-,medium-and high-risk groups(P＜0.01).Both PHI and PHID demonstrated good diagnostic performance in predicting PCa(AUC=0.820 8 and 0.875 7,respectively;all P＜0.001),and in identifying intermediate-to high-risk PCa(AUC=0.838 0 and 0.878 3,respectively;all P＜0.001).Compared to the baseline model,the incorporation of PHI and PHID individually into the multivariate model significantly improved the screening performance for PCa(AUC=0.910 and 0.898,respectively;all P＜0.001).Conclusion PHI and PHID exhibit high diagnostic efficacy in screening PCa,particularly in identifying intermediate-to high-risk disease.
