Research progress in mitochondrial damage and NLRP3 inflammasome signa-ling in age-related macular degeneration
10.13389/j.cnki.rao.2025.0012
- VernacularTitle:线粒体损伤和NLRP3炎症小体信号在年龄相关性黄斑变性中的研究进展
- Author:
Yue ZOU
1
;
Yunqin LI
1
;
Xin TAN
1
;
Junliang JIANG
1
Author Information
1. 650021 云南省昆明市,云南大学附属医院(云南省第二人民医院,云南省眼科医院)
- Publication Type:Journal Article
- Keywords:
age-related macular degeneration;
inflammasome;
mitochondrion;
neuroinflammation
- From:
Recent Advances in Ophthalmology
2025;45(1):60-65
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration(AMD)is a critical ophthalmic condition characterized by substantial vis-ual impairment.Retinal neuroinflammation is one of the fundamental pathophysiological features of AMD.The NOD-like re-ceptor protein 3(NLRP3)inflammasome plays a crucial role in regulating neuroinflammation.It has been demonstrated that the activation of NLRP3 inflammasome is closely correlated with mitochondrial dysfunction,the increased production of reactive oxygen species(ROS),and the anomalous expulsion of mitochondrial DNA in the progression of AMD.There-fore,inhibitors targeting the NLRP3 inflammasome may become a new approach with great potential for AMD treatment.This article rigorously examines the role of mitochondrial impairment and NLRP3 inflammasome signaling in the pathogene-sis of AMD,highlighting current research advancements and prospective trajectories in this evolving field.
