Early Efficacy of Intense Pulsed Light Combined with Non-Ablative Fractional Laser in Preventing Postoperative Pathological Scar Formation and Intervention of Inflammatory Factors
10.13241/j.cnki.pmb.2025.13.012
- VernacularTitle:强脉冲光联合非剥脱点阵激光预防术后病理性瘢痕形成的早期疗效及对炎症因子的干预研究
- Author:
Li-min TIAN
1
;
Yan-qin YU
;
Yang ZHANG
;
Xin-ying YANG
;
Meng-jie WANG
;
Ya-gaer TU
;
Hao-dong CHEN
;
Yue-nan YANG
Author Information
1. 内蒙古科技大学包头医学院第一附属医院皮肤科 内蒙古包头 014010
- Publication Type:Journal Article
- Keywords:
Intense pulsed light;
Non-ablative fractional laser;
Pathological scar;
Early efficacy;
Inflammatory factors
- From:
Progress in Modern Biomedicine
2025;25(13):2181-2187
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the early efficacy of intense pulsed light(IPL)combined with non-ablative fractional laser(NAFL)in preventing postoperative pathological scar formation and intervention of inflammatory factors.Methods:93 patients with postoperative pathological scar formation who were admitted to our hospital from March 2022 to September 2024 were selected,they were divided into control group A(silicone gel treatment,n=31),control group B(NAFL on the basis of control group A,n=31)and study group(IPL on the basis of control group B,n=31)using the random number table method.The clinical efficacy,simple quality of life scale(SF-36),vancouver scar scale(VSS),inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)],and adverse reactions among three groups were compared.Results:The clinical total effective rate in the study group were higher than those in the control group A and control group B(P＜0.05).SF-36 increased sequentially and VSS decreased sequentially in control group A,control group B,and study group after treatment(P＜0.05).CRP,IL-6,and TNF-α decreased sequentially in control group A,control group B,and study group after treatment(P＜0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P＞0.05).Conclusion:IPL combined with NAFL in preventing postoperative pathological scar formation,can effectively reduce scar formation,reduce inflammatory factors levels,improve patients' quality of life,and be safe and reliable.
