Clinicopathological features and research progress of Langerhans cell sarcoma
10.13315/j.cnki.cjcep.2025.08.014
- VernacularTitle:朗格汉斯细胞肉瘤的临床病理学特征及研究进展
- Author:
Yu XIONG
1
;
Sha ZHAO
1
Author Information
1. 四川大学华西医院病理科,成都 610000
- Publication Type:Journal Article
- Keywords:
Langerhans cell sarcoma;
clinicopathological features;
biological mechanisms;
literature review
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(8):1062-1065,1071
- CountryChina
- Language:Chinese
-
Abstract:
Langerhans cell sarcoma(LCS)is a rare malignant tumor derived from Langerhans cell histiocytes with unique clinicopathological,immunophenotypic,ultrastructural and molecular genetic features.Most studies on LCS are case reports,and the immunohistochemical features,biological mechanisms and molecular basis of the tumor remain to be further elucidated.A large body of literature suggests that LCS is extremely aggressive and presents many difficulties in clinical diagnosis,so it is important to accurately diagnose LCS.In this paper,we will review the clinical,patholog-ical and molecular features of LCS to provide more ideas for the definitive diagnosis of LCS and providing a basis for the selection of treatment regimens for LCS.
