Effect of age on myocardial remodeling in acute anterior myocardial infarction pa-tients after intervention
10.20039/j.cnki.1007-3949.2025.01.006
- VernacularTitle:年龄对急性前壁心肌梗死患者介入术后心肌重构的影响
- Author:
Ming YU
1
;
Yuxing WANG
;
Song YANG
;
Baole LIU
;
Xinyu ZHAO
;
Jinglin ZHAO
;
Jiajie MEI
;
Zhenzhu LIU
;
Peng QU
;
Nan NIU
Author Information
1. 大连医科大学附属第二医院心内科,辽宁省大连市 116027
- Publication Type:Journal Article
- Keywords:
age;
acute anterior myocardial infarction;
percutaneous coronary intervention;
diastolic function
- From:
Chinese Journal of Arteriosclerosis
2025;33(1):38-44
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effect of age on myocardial remodeling after percutaneous coronary intervention(PCI)in patients with acute anterior myocardial infarction.Methods This study was a cross-sectional study analyzing clinical data of regular follow-up at 1,3,6 and 12 months after PCI for acute anterior myocardial infarction.According to the age of the patients,they were divided into a low age group(＜65 years old)and a high age group(≥65 years old).The differences in baseline data,biochemical indexes,coronary angiography,inflammatory factor levels,and cardiac ultrasound indexes between the two groups were analyzed,and the correlation analysis between age and inflammatory factors and the multivariate linear regression analysis of diastolic function were performed.Results A to-tal of 87 patients with acute anterior myocardial infarction were selected,aged(62±13)years,including 67 males(77.0％),43 in the low age group and 44 in the high age group.Compared with the low age group,the levels of inflam-matory factors such as C-reactive protein,interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)increased in the high age group,while ultrasound indicators such as mitral valve annulus septal e',mitral valve flow velocity E/A,and mitral valve annulus sidewall e'decreased(P＜0.05).Older age was an independent risk factor for a decrease in mitral valve flow velocity E/A,mitral valve annulus sidewall e'and mitral valve annulus septal e'in patients with acute anterior myocardial infarction 6 months after PCI(P＜0.05).Conclusion Age is an independent risk factor for reduced diastolic function after PCI in acute anterior myocardial infarction,inflammatory factor such as IL-1β,IL-6 and TNF-α may play a role in the impaired diastolic function after PCI in age-related acute anterior myocardial infarction.
