Research progress on phase separation in cardiovascular diseases
10.20039/j.cnki.1007-3949.2025.01.002
- VernacularTitle:相分离在心血管疾病中的研究进展
- Author:
Yukun XIANG
1
;
Xuejie CAO
1
;
Baoqi YU
1
Author Information
1. 首都医科大学基础医学院生理学与病理生理学系,北京市 100069;首都医科大学心血管重塑相关疾病教育部重点实验室,北京市 100069;首都医科大学代谢紊乱相关心血管疾病北京市重点实验室,北京市 100069
- Publication Type:Journal Article
- Keywords:
cardiovascular disease;
phase separation;
driving forces of phase separation;
gene expression regulation
- From:
Chinese Journal of Arteriosclerosis
2025;33(1):9-15
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,more and more studies have found that phase separation plays an important role in the onset and progression of cardiovascular diseases.Phase separation refers to the process in which biological macromole-cules,such as proteins and nucleic acids,spontaneously segregate into concentrated and diluted phases under certain con-ditions.This process creates distinct functional compartments within cells and is involved in various cellular biological functions.The driving forces of phase separation include multivalent interactions such as electrostatic interactions,hydro-phobic interactions,and π-π stacking.Key protein regions that promote phase separation include intrinsically disordered regions,low complexity domains,folded domains,and nucleic acid binding domains.This article reviews recent progress in understanding the role of phase separation in cardiovascular diseases,including heart failure,myocardial fibrosis,and atherosclerosis,with a particular focus on the last five years of research.Future studies should aim to elucidate the specif-ic mechanisms of phase separation in cardiovascular diseases and explore its potential as a therapeutic target.
