Bidirectional Mendelian randomization analysis of relationship between cytokines and atopic dermatitis
10.3969/j.issn.1000-484X.2025.08.020
- VernacularTitle:细胞因子与特应性皮炎关系的双向孟德尔随机化分析
- Author:
Weijia LI
1
;
Yi PENG
;
Qiao HUANG
;
Pu WANG
;
Min HU
;
Suyue PAN
;
Lingyu LIU
;
Jiahui QI
;
Qian-fan JIANG
;
Yuqing HE
Author Information
1. 广东医科大学公共卫生学院流行病与卫生统计学系,广东医科大学医学系统生物学研究所,东莞 523808
- Publication Type:Journal Article
- Keywords:
Atopic dermatitis;
Cytokines;
Mendelian randomization;
Causal inference
- From:
Chinese Journal of Immunology
2025;41(8):1914-1919
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Bidirectional causal associations of 41 cytokines with atopic dermatitis(AD)were explored based on a Mendelian randomization(MR)approach.Methods:Pooled data from genome wide association study(GWAS)of 41 cytokines and AD were utilized for instrumental variable(IV)screening,and single nucleotide polymorphism(SNP)affecting the results of MR analyses was excluded by the MR-PRESSO outlier test as well as by the MR Steiger filtering method.Two-sample bidirectional MR analyses were performed using inverse variance weighting(IVW),MR-Egger regression,and weighted median methods(WM).MR-Egger intercept term test and Cochran's Q test were performed to test the pleiotropy and heterogeneity of IV,and MR results were visu-alized by scatterplots,funnel plots,and leave-one-out plots.Results:Forward MR analysis showed that MIG(IVW:OR=0.89;95%CI:0.81～0.97;P=0.006)reduced the risk of AD development.In contrast,IL-5(IVW:OR=1.17;95%CI:1.01～1.36;P=0.042)and IL-18(MR Egger:OR=1.17;95%CI:1.03～1.33;P=0.030)increased the risk of AD development.Inverse MR analysis showed a potential causal association between AD and increased MIG(IVW:Beta=0.10;95%CI:0.02～0.17;P=0.014).None of the sensitivity analyses indicated pleiotropy and heterogeneity of the included IV.Conclusion:MIG may be an important marker in the progression of AD with a potential bidirectional causal association with risk of morbidity.IL-5 and IL-18 have a potential positive causal association for AD.
