Lymphocytes and renal fibrosis
10.3969/j.issn.1000-484X.2025.08.042
- VernacularTitle:淋巴细胞与肾脏纤维化
- Author:
Siqi LI
1
;
Luping SHAO
;
Yufei YANG
;
Ying XU
Author Information
1. 大庆市人民医院,大庆 163000;吉林大学白求恩第一医院,长春 130000
- Publication Type:Journal Article
- Keywords:
Lymphocytes;
Fibrosis;
Kidney disease;
Chronic kidney disease
- From:
Chinese Journal of Immunology
2025;41(8):2046-2048,后插1-后插2
- CountryChina
- Language:Chinese
-
Abstract:
Renal fibrosis is a critical factor in progression of chronic kidney disease to end-stage renal disease.Underlying mechanisms driving renal fibrosis remain unclear.Lymphocytes play a pivotal and dual role in initiation and progression of renal fibro-sis.Through secretion of cytokines and chemokines,as well as direct cell-cell interactions,lymphocytes can exert profibrotic effects while also demonstrating antifibrotic potential under certain conditions.This review aims to summarize current research advances regarding interplay between lymphocytes and renal fibrosis and to explore their potential applications in antifibrotic therapies.
