Research on mechanism of epigenetics in cartilage damage of rheumatoid arthritis
10.3969/j.issn.1000-484X.2025.08.039
- VernacularTitle:表观遗传在类风湿关节炎软骨损伤中的作用机制研究
- Author:
Yu LUO
1
;
Wei WEI
1
;
Xin YANG
1
Author Information
1. 成都中医药大学养生康复学院,成都 610075
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis;
Cartilage damage;
Epigenetics
- From:
Chinese Journal of Immunology
2025;41(8):2025-2031
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is a chronic autoimmune disease involving multiple joints,with irreversible cartilage damage and joint dysfunction,which seriously affects quality of life and social participation of patients.At present,efficacy of clinical RA therapy drugs is limited,and new therapeutic targets need to be found.Genes are closely related to RA,and epigenetics is mecha-nism that affects phenotype of genome,it is reversible and specific,which has been widely studied in RA.This article aims to review mechanism of epigenetic regulation in occurrence and development of RA cartilage injury,in order to provide new ideas for clinical treatment of RA.
