Effect of Thunberg Fritillary extract combination with acute inflammatory stimulation on non-small cell lung cancer
10.3969/j.issn.1000-484X.2025.08.002
- VernacularTitle:浙贝母提取物协同急性炎症刺激干预非小细胞肺癌的作用探讨
- Author:
Hanxue WANG
1
;
Shuyan XING
;
Jia YANG
;
Xiaoyun LIU
;
Dongxue YE
;
Guoying ZHANG
;
Rong RONG
;
Yong YANG
Author Information
1. 山东中医药大学,济南 250355
- Publication Type:Journal Article
- Keywords:
Lewis lung carcinoma;
Acute inflammation;
Thunberg Fritillary;
Non-small cell lung cancer
- From:
Chinese Journal of Immunology
2025;41(8):1800-1805
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the growth inhibition of Thunberg Fritillary extract on non-small cell lung cancer.Methods:The Thunberg Fritillary extract was prepared and characterized by UPLC-QE/MS.Replicated Lewis lung carcinoma ectopic tumor-bear-ing mouse model,yeast injection induced acute inflammation,compared the effect of Thunberg Fritillary extract combination with acute inflammation on the growth,tumor volume and tumor suppression rate of Lewis lung carcinoma mice,and determine the content of inflammatory factors by the flow CBA method(IL-6,IL-1β,IL-1α,IL-10,IL-27,IL-17A,IL-12p70,IL-23,TNF-α,IFN-γ,IFN-β,GM-CSF,MCP-1).Results:The inhibition of Lewis lung carcinoma mice was similar to that of cisplatin alone,and the tumor suppression rate was 35%;the tumor suppression rate of Thunberg Fritillary extract combined with acute inflammatory stimulation of yeast was 62%,1.8 times that of cisplatin alone.The decrease in the expressions of cytokines IL-23,MCP-1 after acute inflammatory stimulation in yeast was associated with tumor suppression;while the increased expressions of IL-6,IL-1β,IL-1α,IL-10,IL-27,IL-17A,IL-12p70,TNF-α,IFN-γ,IFN-β and GM-CSF cytokines were associated with tumor suppression.Conclusion:The Thun-berg Fritillary extract combination with acute inflammation can play a positive role against non-small cell lung cancer,which will pro-vide new research ideas and methods for the prevention and treatment of non-small cell lung cancer.
