VSTM1 gene polymorphism associated with its gene expression and systemic lupus erythematosus disease activity in a Han Chinese cohort
10.3969/j.issn.1000-484X.2025.08.030
- VernacularTitle:中国汉族人群VSTM1基因多态性与其基因表达及系统性红斑狼疮活动度的相关性
- Author:
Jing LI
1
;
Jiayi YUAN
;
Xuejing XU
;
Zhen XU
;
Lan WANG
;
Ming ZONG
;
Lieying FAN
Author Information
1. 同济大学附属东方医院检验科,上海 200120
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematosus;
VSTM1;
SIRL-1;
Gene polymorphism
- From:
Chinese Journal of Immunology
2025;41(8):1975-1979
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether the rs612529 C/T and rs11669663 G/A in VSTM1 gene are associated with leukocyte signaling inhibitory receptor-1(SIRL-1)expression and an increased risk for systemic lupus erythematosus(SLE)in a Han Chinese cohort.Methods:A total of 200 patients with SLE and 218 healthy controls(HC)were enrolled.Relevant laboratory characteris-tics of patients with SLE were also collected.Genotyping of rs612529 C/T and rs11669663 G/A were performed by Sanger sequencing technology.SIRL-1 expression was assessed in peripheral blood neutrophils and monocytes was detected by flow cytometry.Levels of autoantibodies associated with SLE were detected by ELISA.Results:In both SLE group and HC,the C allele of rs612529 was asso-ciated with a decreased expression level of SIRL-1 on monocytes,with a gradual increased in SIRL-1 protein level from the CC over the CT to the TT genotype.C allele of rs612529 was associated with higher serum anti-dsDNA antibody titers in patients with SLE(P<0.05).In the case of rs11669663 G/A,no significant association of genotypes with SLE susceptibility was detected.Conclusion:VSTM1 rs612529 C/T may contribute to SLE disease activity and regulate SIRL-1 expression on monocytes in the Han Chinese cohort.
