Research status of relationship between glycocalyx degradation and endothelial cell dysfunction
10.13699/j.cnki.1001-6821.2025.02.027
- VernacularTitle:糖萼降解与内皮细胞功能障碍关系的研究现状
- Author:
Guo-ci LU
1
;
Xing XU
;
Kai LIU
Author Information
1. 甘肃中医药大学中西医结合学院,甘肃 兰州 730000
- Publication Type:Journal Article
- Keywords:
glycocalyx;
endothelial dysfunction;
inflammation;
oxidative stress;
mechanotransduction
- From:
The Chinese Journal of Clinical Pharmacology
2025;41(2):284-289
- CountryChina
- Language:Chinese
-
Abstract:
The glycocalyx(GC)constitutes an essential component of the vascular endothelial cell surface,facilitating vasodilation,regulating vascular permeability,modulating leukocyte adhesion,and exerting anti-inflammatory effects.Under the influence of diverse pathological factors,GC degradation is triggered,and endothelial cell dysfunction is mediated through various mechanisms such as oxidative stress,exacerbated inflammatory responses,abnormal mechanical transduction,and augmented white blood cell adhesion.Furthermore,dysfunctional endothelial cells can also lead to an intensification of GC degradation.In this paper,the potential correlation between GC degradation and endothelial cell dysfunction,along with related drug intervention studies,were summarized and analyzed,which provided ideas for subsequent drug research and pave the way for improving clinical efficacy of related diseases.
