Evaluating the relationship between glucose metabolic status and neonatal weight by using regression discontinuity analysis
10.13602/j.cnki.jcls.2025.08.08
- VernacularTitle:利用断点回归分析孕期糖代谢状态与新生儿出生体重的关系
- Author:
Ran ZHANG
1
;
Shanshan HOU
;
Junfeng MA
;
Ying MENG
;
Mingyuan JIAO
Author Information
1. 北京市通州区妇幼保健院 检验科,北京 101101
- Publication Type:Journal Article
- Keywords:
metabolic status of glucose;
newborn weight;
regression discontinuity analysis
- From:
Chinese Journal of Clinical Laboratory Science
2025;43(8):591-595
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore relationship between glucose metabolism and neonatal weight in high-risk gestational diabetes melli-tus(GDM).Method A retrospective study was conducted on 779 pregnant women who underwent prenatal examinations at Tongzhou Maternity and Child Health Care Hospital in Beijing from March to June 2022.The data on pre-pregnancy weight,mid-and late-preg-nancy glycated albumin(GA)and glycated hemoglobin(HbA1c),pre-delivery weight,gestational weight gain,and neonatal birth weight were collected.A GDM risk assessment model was established using multivariate logistic regression to classify pregnant women into high-risk and low-risk groups for GDM,followed by separate management strategies.Regression discontinuity(RD)analysis was applied to evaluate the relationship between gestational glucose metabolism status and neonatal birth weight.Results Among the 779 pregnant women,the overall incidence of macrosomia was 7.32％.The high-risk GDM group exhibited significantly higher pre-pregnan-cy weight,late-pregnancy HbA1c,and GA levels compared to the low-risk group(all P＜0.001).Neonatal birth weight in the high-risk group was significantly higher than that in the low-risk group(P＜0.05),with a significantly increased macrosomia incidence(13.55％vs 5.77％,P＜0.05).RD analysis revealed a jump reduction of 199.59 g(P=0.029)in neonatal birth weight at the risk score thresh-old.Conclusion Lifestyle glucose metabolism management in high-risk GDM pregnant women may effectively reduce neonatal birth weight,mitigated the trend of excessive gestational weight gain,and improved late-pregnancy HbA1c and GA levels,providing evi-dence-based support for maternal and child health services.
