Long noncoding RNAs related to osteoporosis:current research status and developmental trends
- VernacularTitle:骨质疏松症相关长链非编码RNA:研究现状及发展趋势
- Author:
Wangxiang WU
1
;
Dongcheng RAN
;
Jiamu XU
;
Jiafu XU
;
Jingjing CHEN
;
Chunqing WANG
Author Information
- Publication Type:Journal Article
- Keywords: osteoporosis; long non-coding RNA; bibliometrics; visualization analysis; Cite Space; osteoblasts; osteoclasts; differentiation
- From: Chinese Journal of Tissue Engineering Research 2025;29(29):6360-6368
- CountryChina
- Language:Chinese
- Abstract: BACKGROUND:Studies have indicated that long noncoding RNAs play a crucial role in the pathogenesis and progression of osteoporosis.Thus,it is essential to comprehend the current research status,hotspots,and developmental trajectories of long noncoding RNAs in the field of osteoporosis research.OBJECTIVE:To explore the research status,development trends,and hotspots in the field of osteoporosis-related long noncoding RNAs by conducting bibliometric statistics and visualization analysis of the relevant literature.METHODS:Using the search string"(TS=(Osteoporosis OR Osteoporoses)AND TS=(Long non coding RNA OR LncRNA OR Lnc RNA OR Long noncoding RNA)),"a subject term search was conducted in the Web of Science Core Collection database for articles published from January 2015 to September 2024.After manual filtering of the obtained raw data,visualization analysis of authors,institutions,countries,and keywords was performed using Cite Space 6.2.R4 software and Microsoft 365(Office).RESULTS AND CONCLUSION:A total of 265 articles were included from the Web of Science Core Collection database.Since 2015,there has been an overall upward trend in the number of publications in this field,with China being the leading country in terms of publication volume and research centrality,while Beihang University holds the highest institutional centrality.After keywords directly related to the article's theme were excluded,the terms"osteogenic differentiation,""expression,""bone formation,"and"mesenchymal stem cells"emerged as core topics based on co-occurrence frequency and centrality.A comprehensive analysis of the keyword cluster map,keyword burst map,and keyword timeline map reveals that investigating the mechanisms by which long non-coding RNAs influence the formation and differentiation of osteoblasts,as well as the differentiation of osteoclasts and bone resorption,constitutes both a current research hotspot and a future research trend in this field.
