Progress in mutual regulation of lncRNA and METTL3 in tumors
10.3969/j.issn.1000-4718.2025.08.022
- VernacularTitle:lncRNA与METTL3在肿瘤中相互调控的研究进展
- Author:
Han XU
1
;
Yi ZHANG
;
Xin WANG
;
Zichen WEI
;
Mingchao ZHAO
;
Lei PANG
Author Information
1. 扬州大学附属医院消化内科,江苏 扬州 225003;扬州大学医学院/江苏省非编码RNA基础与临床转化重点实验室,江苏 扬州 225009
- Publication Type:Journal Article
- Keywords:
RNA modification;
N6-methyladenosine;
METTL3;
long noncoding RNA;
tumor
- From:
Chinese Journal of Pathophysiology
2025;41(8):1639-1645
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetic modifications of RNA play a crucial role in the initiation and progression of tumors.Among these modifications,N6-methyladenosine(m6A)modification catalyzed by the METTL3 methyltransferase is one of the most common RNA modifications.It is essential for regulating RNA transcription,stability,and translation.At the same time,long non-coding RNAs(lncRNAs)also serve as important regulatory molecules and play a significant role in the development and progression of tumors.However,the reciprocal interaction between lncRNAs and METTL3,as well as their functional mechanisms within tumors,are not fully understood.This paper aims to provide a comprehensive over-view of the mutual regulation between lncRNAs and METTL3 in tumors.The goal is to offer new insights and theoretical foundations for a better understanding of tumor pathogenesis.
