Progress in pathogenesis of angiopoietin-like proteins involved in develop-ment of metabolic associated fatty liver disease
10.3969/j.issn.1000-4718.2025.08.020
- VernacularTitle:血管生成素样蛋白参与代谢相关脂肪性肝病发生发展的机制研究进展
- Author:
Peiran ZHAO
1
;
Xingyu LIU
1
;
Nan AI
1
;
Xinchen WANG
1
;
Rui WANG
1
;
Jing YANG
1
Author Information
1. 黑龙江中医药大学,黑龙江 哈尔滨 150040
- Publication Type:Journal Article
- Keywords:
angiopoietin-like proteins;
metabolic associated fatty liver disease;
lipid metabolism;
insulin re-sistance;
angiogenesis
- From:
Chinese Journal of Pathophysiology
2025;41(8):1626-1632
- CountryChina
- Language:Chinese
-
Abstract:
Angiopoietin-like proteins(ANGPTLs)are a family of proteins that are structurally similar to angio-poietin.So far,eight ANGPTLs have been discovered,namely ANGPTL1 to ANGPTL8.They are not only angiogenic fac-tors,but also play a pivotal role in various pathophysiological processes such as glucose and lipid metabolism,redox regu-lation,chronic inflammation and cancer,and having a close connection with the occurrence and development of metabolic diseases.This review focuses on the mechanism of action of ANGPTLs in metabolic associated fatty liver disease,in order to make a contribution to the prevention and treatment of MAFLD and concurrent diseases.
