Research advances of mesenchymal stem cells in the bone marrow microenvironment of acute myeloid leukemia

VernacularTitle:间充质干细胞在急性髓系白血病骨髓微环境中的研究进展
Author: Xingyu WAN ¹ ; Nan LI ; Shuiqing LIU ; Xi ZHANG
Author Information

1. 陆军军医大学第二附属医院血液病医学中心、血液病与微环境重庆市重点实验室,重庆 400037
Publication Type:Journal Article
Keywords: acute myeloid leukemia; mesenchymal stem cell; bone marrow microenvironment; cancer-promoting effect; targeted therapy
From: The Journal of Practical Medicine 2025;41(2):294-299
CountryChina
Language:Chinese
Abstract: Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy,driven by multiple gene mutations and characterized by high incidence and mortality rates. Mesenchymal stem cells (MSCs),which possess self-renewal and multidirectional differentiation potentials,play crucial roles within the bone marrow microenvironment. Emerging research has demonstrated that MSCs contribute to AML development through various mechanisms,including mitochondrial transfer,transmission of extracellular vesicles,adipogenic differentiation,and secretion of pro-cancer proteins. This review provides a comprehensive summary of the involvement of MSCs in the AML bone marrow microenvironment and offers insights for developing novel therapeutic strategies targeting MSCs in AML treatment.