Research progress in in vitro testing methods of developmental neurotoxicity
10.3867/j.issn.1000-3002.2025.08377
- VernacularTitle:神经发育毒性体外测试方法研究进展
- Author:
Huan LUO
1
;
Gonghua TAO
1
;
Ping XIAO
1
Author Information
1. 上海市疾病预防控制中心,国家药品监督管理局化妆品监测评价重点实验室,上海 201107;上海市疾病预防控制中心,国家环境保护新型污染物环境健康影响评价重点实验室,上海 201107
- Publication Type:Journal Article
- Keywords:
developmental neurotoxicity;
neural stem cells;
in vitro testing battery;
in vitro testing model;
risk assessment;
toxicity prediction
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(8):631-638
- CountryChina
- Language:Chinese
-
Abstract:
Developmental neurotoxicity(DNT)has been recognized as an important aspect of risk assessment.However,traditional in vivo tests are limited by an increasing need to assess the risk of numerous industrial chemicals.The DNT in-vitro testing battery(DNT IVB)has emerged that can reduce animal use with potential cost-efficiencies.In this article,the progress and targets of DNT IVB are explored in general and the DNT in vitro testing methods and alternative in vitro models in particular.The appli-cability of DNT in vitro testing data based on integrated approach to testing and assessment(IATA)is evaluated.In conclusion,with the development of high-throughput screening and human-derived cell models,DNT IVB can better align with priority testing requirements in modern DNT risk assessment frameworks and deliver validated in vitro alternatives for regulatory compliance.
