Research progress on the antitumor effects of immune checkpoint inhibitors
10.3969/j.issn.1006-5725.2025.02.020
- VernacularTitle:免疫检查点及抑制剂抗肿瘤作用的研究进展
- Author:
Qiang FU
1
;
Zhongqi LU
;
Ying CHANG
;
Tiefeng JIN
;
Meihua ZHANG
Author Information
1. 延边大学附属医院超声医学科,吉林延吉 133000;延边大学肿瘤研究中心,吉林延吉 133000
- Publication Type:Journal Article
- Keywords:
tumor;
immunotherapy;
immune checkpoints;
inhibitors
- From:
The Journal of Practical Medicine
2025;41(2):288-293
- CountryChina
- Language:Chinese
-
Abstract:
Tumor immunotherapy has emerged as a highly esteemed and rapidly evolving field in recent years,marked by the development of numerous significant therapeutic approaches. Among these,immune checkpoint inhibitors stand out as a pivotal strategy,attracting considerable attention due to their substantial research progress. This article provides a comprehensive review of the current research advancements in ten key immune checkpoints related to anti-tumor therapy,including PD-1/PD-L1,CTLA-4,LAG-3,TIM-3,TIGIT,and VISTA. By conducting an in-depth analysis of their mechanisms of action,clinical applications,and future research directions,this review aims to offer valuable insights and guidance for optimizing strategies in tumor immunotherapy.
