Three-stage treatment of pediatric lupus nephritis based on the"pathogens latent in the triple burner membrane"theory
10.3969/j.issn.1006-2157.2025.08.009
- VernacularTitle:基于"邪伏焦膜"理论三期辨治儿童狼疮性肾炎
- Author:
Lingjia REN
1
;
Xia ZHANG
;
Jixiang XU
;
Chundong SONG
;
Xianqing REN
;
Ying DING
Author Information
1. 河南中医药大学儿科医学院 郑州 450046
- Publication Type:Journal Article
- Keywords:
pediatric lupus nephritis;
sanjiao membrane system theory;
latent pathogen theory;
stage-oriented pattern differentiation and treatment
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(8):1115-1120
- CountryChina
- Language:Chinese
-
Abstract:
Pediatric lupus nephritis(LN),the most severe visceral complication of systemic lupus erythematosus,is characterized by hematuria,proteinuria,and progressive renal dysfunction.It typically presents with an insidious onset,rapid progression,a prolonged disease course,and an unfavorable long-term prognosis.Currently,no consensus exists on the etiology,pathogenesis,or diagnostic-treatment framework for pediatric LN.Based on clinical experience,the proposed core pathogenesis involves"latent pathogens in the triple energizer membrane system with deficiency-induced toxin activation."This mechanism entails the intermingling of heat and blood stasis,forming pathogenic factors that lodge within the triple energizer membrane system.In states of healthy qi deficiency,internal and external factors interact,allowing pathogenic toxins to damage the viscera via the triple energizer membrane network,ultimately targeting the kidneys.The disease progression is classified into three distinct phases.In the latent pathogen phase,internal or external pathogens accumulate in the triple energizer membrane system.Treatment emphasizes pathogen elimination,heat clearance,and healthy qi preservation.In the active renal involvement phase,latent pathogens rapidly disseminate systemically via the membrane network,destabilizing renal essence and causing micro-substance leakage.Treatment focuses on toxin resolution,stasis dispersion,membrane regulation,and renal stabilization.During the triple energizer residual phase,incomplete restoration of healthy qi permits the persistence of dormant pathogens,predisposing to reactivation.Therapeutic focus during this phase includes qi consolidation to restore primordial essence,residual pathogen clearance,and mitigating disease recurrence to delay chronic renal deterioration.This phase-specific differentiation-treatment strategy aims to address disease complexity while optimizing therapeutic outcomes through targeted interventions.
