Analysis of Inflammatory Indexes and Microecological Characteristics of Vaginal Secretions in Patients with Fungal Vaginitis
10.3969/j.issn.1671-7414.2025.01.034
- VernacularTitle:真菌性阴道炎患者阴道分泌物炎性指标及微生态特征分析研究
- Author:
Weiwei XIE
1
;
Haojue WANG
1
;
Yanmei CHE
1
Author Information
1. 无锡市锡山人民医院妇产科,江苏无锡 214100
- Publication Type:Journal Article
- Keywords:
fungal vaginitis;
vaginal secretion;
inflammatory index;
microorganism;
cervical lesion
- From:
Journal of Modern Laboratory Medicine
2025;40(1):179-184,188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the inflammatory indexes and microecological characteristics of vaginal secretions in patients with fungal vaginitis. Methods 320 patients with fungal vaginitis admitted to Wuxi Xishan People's Hospital from January 2019 to January 2022 were selected. According to pathological examination,the patients were divided into A:[simple fungal vaginitis group (n=216)]and B:[fungal vaginitis with cervical lesions group (n=104)]. The clinical data and vaginal microbiological indexes of the two groups were compared. The risk factors of cervical lesions were analyzed using a random forest algorithm. Results The number of patients with vaginal pH>4.5,the numbet of patients with vaginal secretions in grade Ⅲ to Ⅳ and the levels of TNF-α,IL-2 and IL-12 in group B were higher than those in group A(t/x2=4.862～12.924),CRP,IL-4,IL-6 and IL-10 were significantly lower than those in group A(t=9.025～12.962),with statistical significance(all P<0.05),respecitively. Group A has the largest proportion of Lactobacillus crispatus (18.89％) and group B has the largest proportion of Lactobacillus iners (27.05％). The diversity of vaginal microflora in group B was significantly higher than that in group A. The dominant bacterial species in group A were Lactobacillus crispatus and Lactobacillus helyeticus,and the dominant bacterial species in group B were Staphylococcus aureus,Bifidobacterium breve,Lactobacillus iners and Bacteroides fragilis. Compared with group A,the abundances of Glycosyltransferases,Fatty acid biosynthesis and Transporters in group B were significantly reduced. Nicotinate and nicotinamide metabolism and Glycerophospholipid metabolism. The abundances of pathways such as metabolism,Prenyltransferases and Amino acid related enzymes were significantly increased. Random forest analysis showed that Lactobacillus iners,Lactobacillus crispatus,Staphylococcus aureus,Gardnerella vaginalis,Bacteroides fragilis and Bifidobacterium breve were important bacteria groups affecting cervical lesions. Conclusion The microbial composition ratio in vaginal secretions of different patients is different,and the diversity of vaginal flora in patients with fungal vaginitis accompanied by cervical lesions is higher than that in patients with simple fungal vaginitis,Lactobacillus iners,Lactobacillus crispatus,Lactobacillus crispatus,Lactobacillus iners,Lactobacillus crispatus,Staphylococcus aureus,Gardnerella vaginalis,Bacteroides fragilis and Bifidobacterium breve are important groups of bacteria affecting cervical lesions.
