Detection and Diagnostic Value of Serum cTnⅠ,NSE Levels in Patients with Cryptogenic Stroke with Patent Foramen Ovale
10.3969/j.issn.1671-7414.2025.01.030
- VernacularTitle:卵圆孔未闭导致隐源性卒中患者血清cTnⅠ,NSE水平检测及诊断价值研究
- Author:
Haiyan ZHAO
1
;
Yuan LI
;
Peng WANG
Author Information
1. 达州市中心医院神经内科,四川达州 635000
- Publication Type:Journal Article
- Keywords:
cardiac troponin Ⅰ;
neuron specific enolase;
patent foramen ovale;
cryptogenic stroke
- From:
Journal of Modern Laboratory Medicine
2025;40(1):158-162,168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and diagnostic value of serum cardiac troponin Ⅰ (cTn Ⅰ ) and neuron-specific enolase protein (NSE) in patients with cryptogenic stroke caused by patent foramen ovale (PFO). Methods A total of 108 patients with PFO admitted to Dazhou Central Hospital from December 2020 to December 2022 were selected and divided into 32 patients with cryptogenic stroke group (stroke group) and 76 patients with non-cryptogenic stroke group (non-stroke group) according to whether the patients caused cryptogenic stroke. According to the National Institutes of Health Stroke Scale (NIHSS),they were divided into mild group (<4points,n=10),moderate group (4～15points,n=15) and severe group (>15points,n=7). levels of fibrinogen (FIB),C-reactive protein (CRP),and alanine aminotransferase (ALT) were measured by an automatic biochemical analyzer in all patients. The serum levels of cTn Ⅰ and NSE were detected by ELISA-diagnostic value of serum cTn Ⅰ and NSE in PFO-induced cryptogenic stroke by ROC curve analysis. Logistic regression was applied to analyze the factors affecting the occurrence of cryptogenic stroke in PFO patients. Results Compared with the non-stroke group,the levels of FIB(3.20±0.36g/L vs 2.95±0.30g/L),CRP(73.58±7.43mg/L vs 62.52±7.11mg/L),ALT (68.58±6.82U/L vs 61.08±6.28U/L),cTn Ⅰ(0.78±0.10ng/L vs 0.58±0.08ng/L)and NSE(37.52±3.82μg/L vs 30.35±3.72μg/L)in the stroke group were increased,and the differences were statistically significant(t=3.722～10.994,all P<0.05). Compared with the mild group,the levels of cTn Ⅰ and NSE in the serum of patients in the moderate and severe groups were increased(t=5.891,7.177;3.458,4.105),the levels of cTn Ⅰ,NSE in the serum of the severe group were significantly higher than those in the moderate group (t=2.474,1.336),the differences were statistically significant (all P<0.05).The AUC (95％ CI) for the combined diagnosis of cryptogenic stroke in PFO patients was[0.981 (0.962～1.000)],which was higher than cTn Ⅰ[0.878(0.864～0.948)],NSE[0.911(0.850～0.972)]diagnosed alone (Z=8.621,6.477,all P<0.001). Logistic regression analysis showed that cTn Ⅰ (OR=2.631,95％CI:1.508～4.591),and NSE(OR=2.841,95％CI:1.514～5.330)were the influencing factors for the occurrence of cryptogenic stroke in PFO patients (P<0.05). Conclusion The serum levels of cTn Ⅰ and NSE in patients with cryptogenic stroke caused by PFO patients are significantly increased,which has certain diagnostic value for patients with cryptogenic stroke.
