Research progress in immunotherapy for Graves′ disease
10.3760/cma.j.cn311282-20241115-00547
- VernacularTitle:Graves病免疫治疗的研究进展
- Author:
Shuo DONG
1
;
Fanrui DING
1
;
Qian XING
1
Author Information
1. 大连医科大学附属第一医院内分泌与代谢病科，大连 116021
- Publication Type:Journal Article
- Keywords:
Graves′ disease;
Immunotherapy;
Thyrotropin receptor antibody
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(10):872-877
- CountryChina
- Language:Chinese
-
Abstract:
Graves′ disease is an autoimmune disorder that can affect the thyroid gland, eyes, and skin. Its pathogenesis involves an imbalance in the immune response, leading to the production of IgG antibodies that stimulate thyroid stimulating hormone receptors on thyroid cells, resulting in increased synthesis and secretion of thyroid hormones. Although traditional treatments have shown certain efficacy, they still have limitations. Given the current understanding of the pathophysiology and immunobiology of Graves′ disease, several novel treatment strategies have emerged, including biological agents, small molecular peptides, immunomodulators, and specific antibodies. These advancements provide additional therapeutic options for the treatment of Graves′ disease.
