A case of zoledronic acid-induced extensive ocular inflammation and literature review
10.3760/cma.j.cn311282-20250222-00089
- VernacularTitle:唑来膦酸致眼部广泛性炎症一例并文献复习
- Author:
Xiaoqing ZHANG
1
;
Xiaoyu CHENG
;
Zhaodong DU
;
Tian LIU
;
Lidan MA
;
Ruixia SUN
;
Ying CHEN
Author Information
1. 青岛大学附属医院内分泌与代谢性疾病科，青岛 266003
- Publication Type:Journal Article
- Keywords:
Zoledronic acid;
Ocular inflammation;
Osteoporosis;
Adverse effects;
Steroid therapy
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(10):861-865
- CountryChina
- Language:Chinese
-
Abstract:
This article reports a case of extensive ocular inflammation following zoledronic acid infusion for the treatment of osteoporosis. The patient developed pain, eyelid edema, conjunctival congestion, and decreased vision in the right eye one day after receiving intravenous zoledronic acid, and was diagnosed with uveitis, scleritis, and periorbital soft tissue inflammation. The patient′s symptoms were evaluated using the clinical activity score(CAS). After high-dose corticosteroid pulse therapy combined with other comprehensive treatments, the symptoms improved markedly. This article reviews the incidence, clinical features, potential mechanisms, management, and prognosis of ocular adverse reactions induced by zoledronic acid, and highlights the importance of early recognition and timely treatment of ocular inflammation after zoledronic acid therapy.
