Comorbid metabolic syndrome and its risk factors of patients with bipolar disorder
10.3760/cma.j.issn.1006-7884.2017.02.005
- VernacularTitle:双相障碍患者共病代谢综合征的风险及危险因素分析
- Author:
Hui XIANG
1
;
Ruizhi MAO
1
;
Guoqing ZHAO
1
;
Zhiguo WU
1
;
Daihui PENG
1
;
Wu HONG
1
;
Kaida JIANG
1
;
Yiru FANG
1
Author Information
1. 200030,上海交通大学医学院附属精神卫生中心心境障碍科
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Metabolic diseases;
Hyperlipidemias
- From:
Chinese Journal of Psychiatry
2017;50(2):107-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective This report aimed at exploring the risk factors impact on metabolic co-morbidities of bipolar disorder (BD).Methods An cross-sectional study was conducted on a total of 206 inpatients and outpatients mnet the DSM-Ⅳ-TR criteria for BD,meanwhile matched 167 healthy controls in age,gender and education.Self-made questionnaire was used to collect data such as general demographic data,clinical information,blood lipid and glucose indexes.The criterion of metabolic syndrome (MetS) and hyperlipidemia was referred to the Chinese adult dyslipidemia prevention guideline proposed at 2007,the international physical activity questionnaire was used to assess activity level,then compaed between groups.And the Chi-square test,one-way analysis of variance and binary Logistic regression analysis were used in our statistical analysis.Results The rate of MetS in BD group was higher than control group significantly (25.7％ vs.9.6％,x2=14.90,P＜0.01),and so was the related metabolic components include body mass index (BMI) (F=11.70,P＜0.01),triglyceride (F=12.17,P＜0.01),the ratio of triglyceride/high-density lipoprotein-C (F=16.17,P＜0.01),systolic pressure (F=37.81,P＜0.01),diastolic pressure (F=57.89,P＜ 0.01),but no difference was found in total cholesterol,low density lipoprotein,blood-glucose,glycated hemoglobin and hyperlipidemia.BD group showed significantly more eating food (x2=19.38,P＜0.01),meaty (x2=14.67,P＜0.01) and insomnia (x2=24.12,P＜0.01),but no difference was found in levels of activity.A binary logistic regression analysis showed BMI (OR=1.562,P＜0.01),gender(OR=8.162,P＜0.01)and total duration (OR=1.011,P＜0.01) were major independent risk factors for MetS.Conclusion It indicafed higher risk of comorbid with MetS in BD patients.Gender,BMI,and total medication time may be the main risk factors.
