A preliminary analysis of effect of onset age on prefrontal activation during working memory task in patients with bipolar disorder
10.3760/cma.j.issn.1006-7884.2017.02.006
- VernacularTitle:不同起病年龄双相障碍患者执行工作记忆任务期间前额皮质激活的研究
- Author:
Yue ZHU
1
;
Wenxiang QUAN
1
;
Yantao MA
1
;
Ju TIAN
1
;
Wentian DONG
1
;
Xin YU
1
Author Information
1. 100191,北京大学第六医院北京大学精神卫生研究所卫生部精神卫生学重点实验室(北京大学)
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Spectroscopy,near-infrared;
Prefrontal cortex;
Onset age
- From:
Chinese Journal of Psychiatry
2017;50(2):114-118
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To assess the effect of onset age on prefrontal activation during a working memory task in patients with bipolar disorder using a 52 multichannel functional near-infrared spectroscopy (NIRS).Methods Sixteen patients with early-onset (EO,onset age≤24 years old) and 14 with non-early-onset (NEO,onset age＞24 years old) bipolar Ⅰ disorder were consecutively recruited from wards of Peking University Sixth hospital between October 2013 and May 2014,also including 16 healthy controls (HC) from community.Three groups of participants were diagnosed using MINI,then accepted a cross-sectional comparison of the relative changes in oxygenated hemoglobin (oxy-Hb) and deoxygenated hemoglobin (deoxy-Hb) during 1-back working memory task.Results Results from single factor analyses suggested that EO group showed a significantly reduced activation in deoxy-Hb in the right inferior prefrontal gyrus region than HC (CH34:-0.091 vs.0.009,Z=-2.542,P=0.033),while a significant increase of deoxy-Hb changes in the right dorsolateral prefrontal cortex (CH13:0.145 vs.-0.025,Z=2.412,P=0.048) and right frontopolar cortex (CH15:0.053 vs.-0.032,Z=2.890,P=0.012) regions than NEO group.There were no significant differences in the oxy-Hb changes among three groups in any channel during task.After being adjusted by multiple factor analyses,no significant difference in prefrontal activation among three groups was observed in any channel.Conclusions Similar pattern of prefrontal activity during 1-back working memory task exits between EO and NEO group,indicating that onset age may have no effect on NIRS prefrontal activation under low memory load in patients with bipolar disorder,which provides a reference for further NIRS studies in bipolar disorder.
