Correlation between Expression of Serum Periostin and UAR Levels in Elderly Patients with Nonvalvular Atrial Fibrillation and Recurrence after Radiofrequency Ablation
10.3969/j.issn.1671-7414.2025.01.026
- VernacularTitle:老年非瓣膜性心房颤动患者血清Periostin,UAR水平表达与射频消融术后复发的相关性研究
- Author:
Dandan DONG
1
;
Yulian JIANG
1
Author Information
1. 首都医科大学附属北京同仁医院心血管中心,北京 100176
- Publication Type:Journal Article
- Keywords:
non valvular atrial fibrillation;
periostin;
uric acid/albumen;
radiofrequency catheter ablation
- From:
Journal of Modern Laboratory Medicine
2025;40(1):138-142
- CountryChina
- Language:Chinese
-
Abstract:
Objective To exploring the correlation between serum periostin,uric acid/albumen ratio(UAR) levels and recurrence after radiofrequency ablation (RFCA) in elderly patients with nonvalvular atrial fibrillation (NVAF). Methods The 108 elderly NAVF patients who received RFCA treatment at the Cardiovascular Center of Peking Tongren Hospital Affiliated to Capital Medical University from January 2019 to October 2022 were selected as the observation group,selected 108 healthy individuals who had medical checkups at Beijing Tongren Hospital Affiliated to Capital Medical University during the same period as the control group,and the patients were followed up for a period of 1 year. And according to the follow-up,they were divided into the recurrence group (n=42) and the non-recurrence group (n=66). Sex,age,body mass index (BMI),history of hypertension,diabetes mellitus,hyperlipidemia,smoking,alcohol consumption,left ventricular ejection fraction (LVEF),left ventricular end-diastolic diameter (LVEDD),white blood cell counts were collected. Enzyme linked immunosorbent assay (ELISA) was applied to detect serum Periostin level. Fully automated biochemical analyzer was applied to measure the levels of serum albumin (ALB) and uric acid (UA),whose ratio was the level of UAR. Logistic regression was applied to analyze the influencing factors of recurrence in NVAF patients after RFCA. Receiver Operating Characteristic (ROC) curve was applied to analyze the predictive value of serum Periostin and UAR levels for recurrence after RFCA in elderly NAVF patients. Results Preoperative Periostin,UAR levels in the observation group were significantly higher than serum Periostin (53.53±6.27ng/L),UAR (4.09±0.78) in the postoperative(50.53±7.23 ng/L,3.41±0.91)and control groups(31.29±4.21 ng/L,1.24±0.27),and the differences were statistically significant (t=3.258,30.603;5.896,35.883,all P<0.05). The LVEF was lower in the recurrent group (51.16％±6.49％) than in the non-recurrent group (55.39％±6.71％),the levels of UAR (4.01±0.92),Periostin (55.77±6.56 ng/L) and percentage of history of hyperlipidemia (66.67％) were higher in the relapse group than those in the non-relapse group (3.02±0.63,47.19±5.44 ng/L,34.85％),and the differences were statistically significant (x2/t=3.234,6.458,7.180,10.426,all P<0.05). Serum Periostin[OR(95％ CI):1.856(1.148～3.000)]and UAR[OR(95％ CI):2.127(1.145～3.951)]were independent risk factors for recurrence after RFCA in patients (P<0.05). The area under the curve (95％ confidence interval)[AUC(95％CI)]of serum Periostin and UAR levels to predict relapse after RFCA in elderly NAVF patients were 0.856(0.776～0.916),0.817(0.731～0.884),respectively,the cutoff values were 53.00 ng/L,3.99,the Youden index was 0.569,0.509,the sensitivity was 88.10％,85.71％ and the specificity was 71.21％,65.15％,respectively. The combined predicted of the AUC(95％CI),Youdon index,sensitivity and specificity by the two method were as flows 0.924 (0.857～0.966),0.736,85.71％ and 87.88％,respectively. The combined prediction was significantly higher than that of each index alone (Z=2.296,2.880,P=0.022,0.004). Conclusion Serum Periostin and UAR levels are upregulated in elderly patients with NAVF,there is a certain correlation with recurrence after RFCA,the combination of the two has a high efficacy in predicting recurrence in elderly NAVF patients after RFCA.
