Study on the application of autologous umbilical cord blood priming of CPB circuit in cardiac surgery for congenital heart disease
10.3760/cma.j.cn112434-20250223-00056
- VernacularTitle:自体脐带血预充CPB管路在新生儿先天性心脏病外科手术中的应用
- Author:
Zirui PENG
1
;
Haiyun YUAN
;
Qingqing MENG
;
Yanli LIU
;
Yumei LIU
;
Pushan ZHANG
;
Runzhang LIANG
;
Jiaxiong WU
;
Abudurexiti NIJIMU·
;
Jing LING
;
Qi LOU
;
Shusheng WEN
Author Information
1. 广东省医学科学院 广东省心血管病研究所 广东省人民医院心外科，广州 510080
- Publication Type:Journal Article
- Keywords:
Congenital heart disease;
Umbilical cord blood;
Neonatus;
Cardiopulmonary bypass;
Transposition of the great arteries
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2025;41(10):589-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical value of autologous umbilical cord whole blood(UCB) priming of the cardiopulmonary bypass(CPB) circuit in neonatal cardiac surgery for congenital heart disease(CHD).Methods:This prospective non-randomized controlled trial included neonates undergoing CHD surgery at Guangdong Provincial People’s Hospital from August 2024 to January 2025. The experimental group used autologous UCB for CPB circuit priming, while the control group used adult allogeneic blood(AAB) priming when UCB was unavailable. Preoperative characteristics, intraoperative CPB and aortic cross-clamping(ACC) times, postoperative ICU stay duration, mechanical ventilation time, and hospitalization length were compared.Results:There were no significant differences in preoperative baseline characteristics between the two groups( P>0.05). At the end of surgery, red blood cell count(RBC), hemoglobin level(Hb), and creatine kinase(CK) showed no significant differences between the groups( P> 0.05). Additionally, perioperative left ventricular ejection fraction(LVEF) demonstrated no statistically significant variations( P>0.05). At surgery completion, the UCB group exhibited lower hematocrit(HCT) and higher blood lactic acid(Lac) levels but these differences resolved by 6 hours postoperatively( P>0.05). The UCB group had higher maximum vasoactive-inotropic scores(VISmax) within 48 hours and longer ICU stays, though total hospitalization and mechanical ventilation durations showed no significant differences( P>0.05). Conclusion:Autologous UCB priming reduces AAB requirements and has minimal impact on postoperative cardiac and pulmonary function recovery, or homeostasis., which is safe and feasible. This study provides evidence supporting the clinical application of UCB priming in CPB circuits.
