Sarcopenia on glucose metabolism: Impact and mechanisms
10.3760/cma.j.cn311282-20240905-00397
- VernacularTitle:肌少症对葡萄糖代谢的影响及机制
- Author:
Tingting HAN
1
;
Mingyu ZHU
1
;
Yaomin HU
1
Author Information
1. 上海交通大学医学院附属仁济医院老年科，上海 200127
- Publication Type:Journal Article
- Keywords:
Sarcopenia;
Diabetes mellitus, type 2;
Glucose metabolism;
Insulin resistance;
Myokines
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(4):350-354
- CountryChina
- Language:Chinese
-
Abstract:
Sarcopenia is characterized by a decline in both skeletal muscle mass and function. Since skeletal muscle is the primary organ responsible for insulin-stimulated glucose uptake, sarcopenia, which occurs with aging, is believed to promote insulin resistance in skeletal muscle, leading to disruptions in glucose metabolism. Growing clinical evidence indicates that decreased muscle function may contribute to the development of type 2 diabetes, while a reduction in muscle mass alone does not appear to be significantly associated with its onset. This review, based on the latest research, summarizes the clinical evidence linking sarcopenia to glucose metabolism abnormalities and potential mechanisms through which impaired muscle function affects glucose metabolism. The goal is to inspire early prevention, intervention, and management of type 2 diabetes by targeting skeletal muscle.
