Meningeal lymphatic vessles promote α-syn efflux in Parkinson's disease
10.3969/j.issn.1006-5725.2025.16.024
- VernacularTitle:脑膜淋巴管促进帕金森病α-突触核蛋白外排的研究进展
- Author:
Die XIAO
1
;
Jun MA
1
;
Ling QI
1
;
Zhaoxie YU
1
;
Ya'nan LI
1
Author Information
1. 湖北中医药大学针灸骨伤学院(湖北 武汉 430000)
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
meningeal lymphatic vessels;
α-synuclein
- From:
The Journal of Practical Medicine
2025;41(16):2604-2610
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD)is a neurodegenerative disorder whose core pathological feature is the abnormal accumulation of pathological α-synuclein(α-syn)in the brain,but there are rare clinical therapeutic modalities that target this.As a hot research topic in recent years,meningeal lymphatic vessels(MLVs)play an important role in central nervous system fluid(CNS)drainage,and can promote the exocytosis and clearance of metabolic wastes such as α-syn from the brain.Regulating the morphology and function of MLVs to promote α-syn exocytosis is likely to become an influential direction for future intervention in PD research and provide new approaches for the clinical therapy of PD.In this article,we will overview 3 aspects of the structure and function of MLVs,the role of MLVs in PD,and the strategy of targeting MLVs to treat PD.
