The predictive value of contrast-enhanced ultrasound parameters combined with serum CXCL9 and IGFBP-3 for recurrence of hepatocellular carcinoma after interventional therapy
10.3969/j.issn.1006-5725.2025.16.019
- VernacularTitle:超声造影参数联合血清CXCL9、IGFBP-3对肝癌介入治疗后复发的预测价值
- Author:
Min MO
1
;
Jingjing LIN
;
Xin LU
;
Jin LU
Author Information
1. 长沙市第一医院超声科(湖南 长沙 410001)
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
intervention therapy;
contrast-enhanced ultrasound param-eters;
chemokine ligand 9;
insulin-like growth factor binding protein 3
- From:
The Journal of Practical Medicine
2025;41(16):2568-2574
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the predictive significance of contrast-enhanced ultrasound parameters in combination with serum levels of chemokine ligand 9(CXCL9)and insulin-like growth factor-binding protein 3(IGFBP-3)for the recurrence of hepatocellular carcinoma following interventional therapy.Methods A total of 212 patients with liver cancer who received interventional therapy at the hospital between June 2022 and Novem-ber 2023 were selected and categorized into Group A(61 cases)and Group B(151 cases)based on whether tumor recurrence occurred within one year following the intervention.Multivariate logistic regression analysis was con-ducted to identify potential influencing factors associated with post-treatment recurrence.The predictive perfor-mance of contrast-enhanced ultrasound parameters combined with serum biomarkers was evaluated using receiver operating characteristic(ROC)curve analysis.Results The levels of several factors including a tumor with a maximum diameter exceeding 3 cm,presence of microvascular invasion,high peak intensity(PI),short time to peak(TTP),short arrival time(AT),elevated serum CXCL9,and decreased serum IGFBP-3 were identified as indepen-dent risk factors for recurrence in patients with hepatocellular carcinoma following interventional therapy(P<0.05).The area under the curve(AUC)for the combination of PI,TTP,AT,along with serum levels of CXCL9 and IGFBP-3,in predicting recurrence after interventional therapy was significantly higher than that of individual fac-tors alone(P<0.05).Conclusions The risk of recurrence in patients undergoing interventional therapy for liver cancer is substantial,and it is influenced by a range of independent risk factors.Combining contrast-enhanced ul-trasound parameters with serum levels of CXCL9 and IGFBP-3 may enhance the predictive accuracy for tumor re-currence in these patients.
