Distinct sleep spindle activity patterns in cognitive subtypes of first-episode schizophrenia
10.3969/j.issn.1006-5725.2025.16.015
- VernacularTitle:首发精神分裂症认知亚型的不同睡眠纺锤波活动特征
- Author:
Caiai SONG
1
;
Hailin JIA
;
Xin LIU
;
Lili ZHANG
;
Yunshu ZHANG
;
Keqing LI
Author Information
1. 河北省精神卫生中心(河北省第六人民医院)(河北 保定 071000);河北大学第六临床医学院(河北 保定 071000)
- Publication Type:Journal Article
- Keywords:
schizophrenia;
cognitive subtypes;
sleep spindles
- From:
The Journal of Practical Medicine
2025;41(16):2541-2548
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the number and categories of cognitive subtypes in individuals with First-Episode Schizophrenia(FES)and to explore the potential neurobiological sleep characteristics associated with these distinct cognitive subtypes.Methods The cognitive functions of 45 patients withFES and 40 healthy controls(HCs)were assessed using the MATRICS Consensus Cognitive Battery(MCCB).Latent profile analysis was employed to identify and classify the cognitive subtypes of FES patients.Furthermore,a full-night polysom-nographic recording was conducted to quantify the characteristics of sleep spindle waves.Subsequently,differ-ences in sleep spindle wave features among the identified cognitive subtypes of FES were analyzed and compared.Results Latent Profile Analysis identified two cognitive subtypes among FES patients:a subtype characterized by severe cognitive impairment(SIS,n=32)and another with relatively preserved cognitive function(CRP,n=13).Compared to healthy controls(HCs,n=40),FES patients exhibited increased spindle wave amplitude dur-ing both N2 and N3 sleep stages.Further analysis revealed that the spindle wave duration during the N2 stage was significantly longer in the SIS subtype compared to both CRP and HCs.Similarly,in the N3 stage,the spindle wave duration was longer in SIS than in CRP.Additionally,spindle wave frequency during the N3 stage was higher in both SIS and HCs compared to CRP.Conclusions The results of this study suggest that variations in the fre-quency and duration of spindle waves among different cognitive subtypes may serve as potential neurobiological markers for distinguishing FES cognitive subtypes.
