Value of serum TFPI-1 combined with NF-κB in prognostic analysis of severe traumatic brain injury
10.3969/j.issn.1006-5725.2025.16.003
- VernacularTitle:重型颅脑损伤患者血清组织因子途径抑制物-1联合核因子-κB在预后预测中的价值
- Author:
Biao LENG
1
;
Dequan HONG
1
;
Ming TAN
1
;
Ming TIAN
1
;
Shanliang XIE
1
;
Yaoran TU
1
Author Information
1. 南昌市第一医院急诊创伤中心(江西 南昌 330008)
- Publication Type:Journal Article
- Keywords:
severe traumatic brain injury;
tissue factor pathway inhibitor-1;
nuclear factor-κB;
prognosis;
influencing factors;
predictive value
- From:
The Journal of Practical Medicine
2025;41(16):2455-2460
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognostic value of serum tissue factor pathway inhibitor-1(TFPI-1)combined with nuclear factor-κB(NF-κB)in severe traumatic brain injury(STBI).Methods The medical re-cords of 127 patients with STBI admitted to the hospital from July 2022 to August 2024 were retrospectively ana-lyzed and followed up for 6 months.They were divided into poor prognosis group(n=53)and good prognosis group(n=74)according to the prognosis of STBI patients.The serum NF-κB level,clinical data and serum TFPI-1 level of the two groups were compared.The factors affecting the adverse prognosis of STBI patients was screened,and the value of serum NF-κB and serum TFPI-1 in predicting the adverse prognosis of STBI patients were ana-lyzed.Results The serum NF-κB level in the poor prognosis group was higher than good prognosis group,and the serum TFPI-1 level was lower than good prognosis group(P<0.05).The proportion of patients aged>60 years old was higher than good prognosis group(P<0.05).Serum TFPI-1 level(OR=0.328,95%CI:0.156～0.689)was a protective factor for poor prognosis in STBI patients(P<0.05),serum NF-κB level(OR=3.773,95%CI:1.797～7.924)and age>60 years(OR=3.543,95%CI:1.687～7.441)were independent risk factors for poor prognosis in STBI patients(P<0.05).The area under the curve(AUC)of serum TFPI-1 and NF-κB levels and their combined prediction of poor prognosis in STBI patients were 0.784,0.847 and 0.931,respectively(P<0.05),and the AUC value of the combined TFPI-1 and NF-κB levels was higher(P<0.05).Conclusion Serum NF-κB combined with serum TFPI-1 has higher prognostic value in STBI patients.
