MR imaging characteristics of general paresis of the insane with bilateral hippocampal atrophy as a primary feature

VernacularTitle:以双侧海马萎缩为主要特征的麻痹性痴呆MR影像表现
Author: Yue ZHANG ¹ ; Zhiyan XIE ; Shuangshuang SONG ; Xuejun LIU ; Guizhi XU
Author Information

1. 青岛大学附属医院放射科,山东青岛 266003
Publication Type:Journal Article
Keywords: general paresis of the insane; neurosyphilis; hippocampal atrophy; magnetic resonance imaging
From: Journal of Practical Radiology 2025;41(8):1271-1274
CountryChina
Language:Chinese
Abstract: Objective To analyze the MR imaging features of patients with general paresis of the insane(GPI),characterized by bilateral hippocampal atrophy,and to explore how to improve the accuracy of early GPI diagnosis.Methods A retrospective analysis was conducted on the clinical manifestations,brain imaging data,diagnosis and treatment of 11 patients with GPI.Results Among the 11 cases,MRI showed that 9 cases had varying degrees of brain atrophy,of which 7 cases showed age-inappropriate brain atro-phy,especially bilateral hippocampal atrophy as the main sign,and the remaining 2 cases showed brain atrophy accompanied by multi-ple abnormal intracranial signals;2 cases only showed multiple abnormal intracranial signals.Conclusion MR imaging findings of GPI often manifests only age-inappropriate brain atrophy,particularly bilateral hippocampal atrophy,a feature that holds significant diagnostic value for early detection with reducing missed diagnosis rate of GPI.