Prognostic value of the combination of serum LGALS3BP and GDF-15 in patients with severe acute pancreatitis
10.3969/j.issn.1005-6483.20240506
- VernacularTitle:血清半乳糖凝集素3结合蛋白生长分化因子-15联合对重症急性胰腺炎病人的预后价值
- Author:
Bo HAO
1
;
Xia WANG
;
Ting ZHANG
Author Information
1. 710077 西安,西安医学院第一附属医院消化内科
- Publication Type:Journal Article
- Keywords:
severe acute pancreatitis;
lectin galactoside binding soluble 3 binding protein;
growth differentiation factor-15;
prognosis
- From:
Journal of Clinical Surgery
2025;33(7):693-696
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic value of lectin galactoside binding soluble 3 binding protein(LGALS3BP)and growth differentiation factor-15(GDF-15)in patients with severe acute pancreatitis(SAP).Methods Ninety patients with SAP(SAP group)and 90 patients with mild pancreatitis(MAP)and moderately severe acute pancreatitis(MSAP)(non-SAP group)who attended the First Affiliated Hospital of Xi'an Medical College from January 2021 to January 2024 were foresight selected.The SAP group was separated into a good group(47 cases)and a bad group(43 cases)according to prognosis.Clinical data and relevant testing indicators were collected from the researchers.Compare the levels of serum LGALS3BP and GDF-15 in the SAP group and the non-SAP group;conduct Pearson correlation analysis;perform multivariate Logistic analysis to identify the influencing factors for the prognosis of SAP patients;and use ROC curve analysis to evaluate the value of serum LGALS3 BP and GDF-15 in predicting the prognosis of SAP patients.Results Compared with the non-SAP group group,the serum LGALS3BP and GDF-15 levels in the SAP group were greatly increased(65.26 ng/ml vs.118.63 ng/ml,1763.46 ng/ml vs.2534.83 pg/ml,P＜0.05).There was a positive correlation between serum LGALS3BP and GDF-15(r=0.479,P＜0.05).The expression levels of LGALS3BP and GDF-15 were lower in SAP patients at 48 h and 72 h after admission than at 24 h after admission,and the expression levels of LGALS3BP and GDF-15 were lower in SAP patients at 72 h after admission than at 48 h after admission(P＜0.05).Compared with the poor group,the serum levels of LGALS3BP and GDF-15 in the good group were greatly reduced(135.13 ng/ml vs.103.53 ng/ml,2879.63 pg/ml vs.2219.37 pg/ml,P＜0.05).Compared with the poor group,the C-reactive protein and BISAP scores of SAP patients in the good group were greatly reduced(P＜0.05).LGALS3BP and GDF-15 were risk factors affecting the prognosis of SAP(P＜0.05).The AUC of serum LGALS3BP for predicting the prognosis of SAP patients was 0.897,with sensitivity and specificity of 81.40％and 93.62％,respectively.The AUC of serum GDF-15 in predicting the prognosis of SAP patients was 0.897,with sensitivity and specificity of 76.74％and 93.62％,respectively.The AUC for predicting the prognostic effect in SAP patients with serum LGALS3BP and GDF-15 combination was 0.974,with sensitivity and specificity of 95.35％and 89.36％,respectively.The Zcombination-LGALS3BP and Zcombination-GDF-15 was 2.194 and 2.227,respectively,with P＜0.05.Conclusion Serum LGALS3BP and GDF-15 expression levels are elevated in SAP patients and have a poor prognosis SAP patients have higher serum LGALS3BP and GDF-15 expression levels.Elevated serum LGALS3BP and GDF-15 are detrimental to patient prognosis,and the combination of the two may be used in the future for prognostic assessment of patients with SAP.
