Exploration of the Prevention and Treatment of Peritoneal Dialysis-Related Peritoneal Fibrosis with Invigorating Qi,Detoxif-ying,and Resolving Stasis Method Based on Collateral Disease Theory
10.14148/j.issn.1672-0482.2025.1021
- VernacularTitle:基于络病理论探讨益气解毒化瘀法防治腹膜透析相关腹膜纤维化
- Author:
Yongqing YOU
1
;
Manshu YU
;
Yun SHAN
;
Rong XU
;
Jin YAN
;
Jinyi SUN
;
Meixiao SHENG
Author Information
1. 南京中医药大学附属医院,江苏 南京 210029
- Publication Type:Journal Article
- Keywords:
peritoneal dialysis;
peritoneal fibrosis;
collateral disease;
TCM pathogenesis;
invigorating qi,detoxifying and resol-ving stasis
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(8):1021-1026
- CountryChina
- Language:Chinese
-
Abstract:
Peritoneal fibrosis(PF)is an important reason that restricts long-term treatment of peritoneal dialysis(PD).Based on the theory of collateral disease,PF is considered to be an abdominal collateral disease,with dampness as the main pathogenic factor,and collateral qi deficiency and stagnation,toxicity and blood stasis as the core pathogenesis.The peritoneum is chronically exposed to an inflammatory microenvironment induced by non-biocompatible peritoneal dialysis fluid,reflecting the pathogenic mechanism of dampness-induced pathology.The resultant pathological processes,including damage of peritoneal mesothelial cells,accumulation of inflammatory mediators and metabolic products,and angiogenesis—elucidate the scientific connotation of dampness impairing collaterals and inducing deficiency,toxicity,and stasis.On this basis,the treatment principles of invigorating qi,detoxifying,resolving stasis and unblocking collaterals were proposed,and the Qixue Huazheng prescription was formed with Astragalus as the main ingredient and Centella asiatica and Ligusticum wallichii as the compatibility,which provides a reference for the prevention and treatment of PD-relat-ed PF by traditional Chinese medicine.
