Analysis of the clinical characteristics of Zoletil 50 poisoning
10.3969/j.issn.1004-1648.2025.04.016
- VernacularTitle:舒泰50中毒的临床特征分析
- Author:
Lele ZHONG
1
;
Tianhao YU
1
Author Information
1. 210029 南京医科大学附属脑科医院重症医学科
- Publication Type:Journal Article
- Keywords:
Zoletil 50;
poisoning;
clinical feature
- From:
Journal of Clinical Neurology
2025;38(4):290-293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics of Zoletil 50 poisoning.Methods The clinical data of 33 patients with Zoletil 50 poisoning admitted to our hospital recently were retrospectively analyzed.Results Thirty-two cases were male and 1 case was female in all the 33 patients.Five cases had previous exposure to psychoactive substances such as nitrous oxide,methamphetamine and ketamine,and 19 cases had a history of smoking or drinking alcohol.Limb shaking was in 33 cases(100％),blurred and yellowed vision was in 18 cases(54.55％),unresponsiveness and hypomnesia were in 17 cases(51.52％),hallucination was in 17 cases(51.52％),irritability and panic were in 16 cases(48.48％),insomnia was in 13 cases(39.39％),unfavorable speech was in 9 cases(27.27％),dizziness and lightheadedness were in 8 cases(24.24％),delusion was in 6 cases(18.18％),nausea and vomiting were in 6 cases(18.18％),frequent urination and difficulty in urination were in 5 cases(15.15％),diarrhea and bloating were in 4 cases(12.12％),itchy skin and the abnormal sensation were in 3 cases(9.09％).There was 1 case(3.03％)of epileptic seizure and 1 case(3.03％)of chills.Ataxia was in 29 cases(96.99％),cognitive dysfunction was in 17 cases(51.52％),abnormal tendon reflex was in 13 cases(39.39％),dysarthria was in 9 cases(27.27％),nystagmus was in 6 cases(18.18％),delirium was in 3 cases(9.09％),and vision loss was in 2 cases(6.06％).Auxiliary examinations suggested neutrophil abnormalities in 19 cases(57.58％),elevated transaminases in 21 cases(63.64％),elevated uric acid in 13 cases(39.39％),increased urinary crystals in 8 cases(24.24％),elevated lipids in 11 cases(33.33％),elevated homocysteine in 5 cases(15.15％),and abnormal thyroid hormone abnormalities in 11 cases(33.33％).EEG showed sinus bradycardia in 4 cases(12.12％).Among the 16 patients who underwent EEG examination,there were 2 cases of mild and moderate abnormalities.Among the 6 patients with evoked potentials,there were 5 cases of optic nerve and auditory nerve abnormalities.There were 3 cases of peripheral nerve abnormalities in 7 cases who underwent EMG.Among the 16 patients who underwent cranial MRI examination,there were 3 cases of cortical atrophy,2 cases of white matter degeneration,and 1 case of cerebellar atrophy.Spinal cord MRI showed spinal cord abnormal signal in 1 case.In the treatment,B vitamins were supplemented to control limb shaking,improve sleep,relieve anxiety,control mental symptoms,improve cognition and other symptomatic and supportive therapy.Symptoms were relieved in 29 cases;1 case was discharged automatically;1 case relapsed during treatment,and no significant improvement was observed;2 cases died.Conclusions The specific mechanism of Zoletil 50 poisoning has not been fully clarified,and the main clinical manifestations are significant limb shaking,blurred vision,slow reaction,hallucinations,insomnia,etc.,which can be fatal in severe cases.At present,symptomatic supportive treatment can only mildly relieve the symptoms.
