Research progress of the association between arginase 1 and diabetes-induced vascular endothelial dysfunction
10.3969/j.issn.1006-6187.2025.08.014
- VernacularTitle:精氨酸酶1与糖尿病血管内皮功能障碍相关性的研究进展
- Author:
Dingbang QIU
1
;
Jingwei MIAO
;
Pengdong LI
;
Wenyue JIANG
Author Information
1. 511500 广州医科大学附属清远医院临床研究中心
- Publication Type:Journal Article
- Keywords:
Diabetic angiopathy;
Endothelial dysfunction;
Arginase 1;
p38 Mitogen-activated protein kinase;
Exosomes;
Red blood cells
- From:
Chinese Journal of Diabetes
2025;33(8):635-640
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial dysfunction(ED)is a crucial pathological feature and a key initiating factor in diabetic angiopathy.A major pathway contributing to ED is the reduction of nitric oxide(NO)production.NO is synthesized by endothelial nitric oxide synthase(eNOS)using L-arginine as a substrate.However,arginase(Arg)can compete with eNOS for this substrate.Arg has subtype 1 and 2.In diabetes mellitus(DM),the abnormal increase in Arg1 can lead to excessive consumption of the substrate in the vascular endothelium,which causes a decrease in NO levels,leading to diabetes-induced vascular ED.This article reviews the research progress of arginase 1 in diabetes-induced vascular ED.
